Fig. 1
From: GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment
Gli1 is a prognostic marker in glioma and participates in variety of biological behaviors. a A Kaplan-Meier test estimates the survival for glioma patients. Patients with low expression of Gli1 had a favorable prognosis in the CGCG-array and CGGA-seq (P = 0.0177 and P = 0.0301, respectively). b GSVA with GLI expression. Gene expression signatures of glioma-associated biological behaviors, including the “Hh signaling pathway”, “DNA metabolic process (positive regulation)”, “DNA binding (negative regulation)”, “DNA replication”, “DNA modification”, “protein-DNA complex assembly”, “DNA catabolic process” and “DNA damage response signal transduction by the p53 class mediator” were generated from the Molecular Signature Database. The GLI expression went higher from left to right. A high enrichment score indicates positive correlation with GLI expression and a low enrichment score indicates the reverse