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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment

Fig. 3

GANT61 enhanced the proliferation-inhibiting effect of TMZ. a Cells were cultured in 96-well plates and then treated with solvent only (Control) or increasing doses of TMZ with 5 μM GANT61 for 48 h. Relative proliferation of U87 and U251 cells treated with GANT61 and different doses of TMZ were determined by CCK-8. b Cells were seeded into 96-well plates and then treated with Control, GANT61 (1 μM), TMZ (60 μM) and GANT61 + TMZ for 24 and 48 h. Cell viability was examined using the CCK-8 assay. GANT61 + TMZ treatment resulted in a significant decrease in cell proliferation. Data are mean ± SEM for the three replicates. *P < 0.05, **P < 0.01

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