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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases

Fig. 5

TY-011 induces apoptosis. a and b MGC-803 and SGC-7901 cells were treated with indicated concentration of TY-011 for 48 h. Apoptosis was assessed by flow cytometry after Annexin V/PI staining. Representative images were shown. c and d Quantitation of apoptotic cells in a and b. Data presented are the mean ± SD of three independent experiments. e MGC-803 cells were treated with various concentration of TY-011 for the indicated time. f SGC-7901 cells were treated with various concentration of TY-011 for 48 h. Cells in (e and f) were lysed and subjected for western blot to determine the protein levels of cleaved caspase-3 and PARP-1. The results are representative of three independent experiments

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