Compound | Body weight (g) | Tumor volume (mm3) | T/C (%) | TGI (%) | Tumor weight (g) | Inhibition rate (%) | ||
---|---|---|---|---|---|---|---|---|
Start | End | Start | End | |||||
Control | 22.1 ± 0.2 | 22.6 ± 0.2 | 190.4 ± 6.2 | 783.7 ± 22.7 | / | / | 0.79 ± 0.07 | / |
TY-011 (3 mg/kg) | 20.8 ± 0.1 | 21.8 ± 0.1 | 192.8 ± 7.1 | 433.6 ± 16.2*** | 54.55 | 59.41 | 0.28 ± 0.02*** | 64.9 |
TY-011 (6 mg/kg) | 20.9 ± 0.1 | 20.3 ± 0.2 | 191.2 ± 6.2 | 168.8 ± 7.1*** | 21.82 | 103.77 | 0.10 ± 0.01*** | 87.7 |
TY-011 (9 mg/kg) | 21.4 ± 0.1 | 21.7 ± 0.1 | 189.0 ± 4.9 | 111.4 ± 3.6*** | 14.53 | 113.09 | 0.09 ± 0.01*** | 89.0 |
Irinotecan (50 mg/kg) | 21.2 ± 0.2 | 21.4 ± 0.2 | 191.7 ± 6.7 | 59.3 ± 6.5*** | 8.04 | 122.31 | 0.03 ± 0.01*** | 96.2 |