Fig. 6
Lnc-GNAT1-1 regulates RKIP-NF-κB-Snail circuit in CRC. a Expression of RKIP was decreased or increased following knockdown or overexpression of lnc-GNAT1-1 at the mRNA level. b Protein expression levels of RKIP, NF-Kb and Snail were determined in SW480 and LoVo cells following lnc-GNAT1-1 knockdown or overexpression. c A positive correlation between expression of lnc-GNAT1-1 and RKIP was detected in 68 CRC patients’ cancerous tissues, with R2 = 0.416, P < 0.001. d Rescue experiment showed that reintroduction of RKIP could attenuate the influence of lnc-GNAT1-1 knockdown on proliferation and (e) migration in SW480 cells (Magnification × 100)