Fig. 4

SW IV-134 induces both intrinsic and extrinsic pathways of apoptosis. a PANC-1 and b AsPC-1 cells were treated with SW IV-134 (1 μM), gemcitabine (0.5 μM), and a combination of the two drugs at their respective concentrations. The activation status of caspases 3, 8 and 9 were measured using a Caspase-Glo Assay System (see Methods for details). The data are normalized to the luminescence signals for each caspase on cells treated with DMSO (baseline). (n = 3; **p < 0.01)