Fig. 1

Fbw7 shows reduced expression in non-GCB DLBCL. a for 165 cases of DLBCLs, the classification of GCB and non-GCB groups was previously confirmed by clinical IHC of CD10, Bcl-6 and MUM1; representative IHC cases from GCB and non-GCB patients are shown. b bar chart of Fbw7 expression in the GCB (n = 43) and non-GCB (n = 122) groups. Statistical significance was determined by a two-tailed, Student t test. **, P < 0.01. c IHC staining of Fbw7 in DLBCL, “score ≤ 1” was defined as the low expression group and “score > 1” was defined as the high expression group. Low Fbw7 expression and high Fbw7 expression cases were shown. d Kaplan-Meier survival curve shows a significant association between low Fbw7 levels and poor survival in DLBCL patients (P = 0.004). Low Fbw7 (n = 30), high Fbw7 (n =134) and missing follow-up (n = 1)