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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Oleuropein enhances radiation sensitivity of nasopharyngeal carcinoma by downregulating PDRG1 through HIF1α-repressed microRNA-519d

Fig. 8

Working model of OL action in promoting radiation sensitivity. OL decreases HIF1α expression, which in turn represses miR-519d expression. miR-519d functions to directly target PDRG1 mRNA and inhibit its expression. PDRG1 is able to inhibit radiation sensitivity via the ATM-P53 axis. The overall effect of OL in NPC is then to promote radiation sensitivity

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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