Fig. 6

PFK15 inhibits the tumor growth in a HNSCC xenograft mice model. a The nude mice bearing xenograft were treated with 10 mg/kg and 20 mg/kg PFK15 intraperitoneally (i.p) every other day for 2 weeks. b Tumor growth was measured every other day. c Photos of the xenograft harvested from the nude mice after treatment with PFK15. d The tumor weights were measured after harvest from the carcinoma-bearing mice. e The mice weights were measured to examine the systematic toxicity of PFK15. f The expression of PFKFB3 and Ki67 were detected by immunohistochemistry, and the apoptotic cell death were examined by TUNEL assays. Mean ± S.E.M.; *P < 0.05, **P < 0.01, ***P < 0.001