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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling

Fig. 4

CIP4 promotes the EGF-dependent activation of N-WASP in NPC cells. a 5-8F cells were transfected with control or CIP4-siRNA and whole-cell lysates were immunoblotted for phospho-N-WASP (Y256), total N-WASP and CIP4 at 72 h after transfection. Blots were reprobed for β-actin. b NPC cells transfected with control or CIP4-siRNA were treated with EGF for 1 min, lysed and probed for phospho-N-WASp (Y256) and then reprobed for total N-WASp and CIP4. Blot is representative of three independent experiments. c densitometric quantification of immunoblot in b

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