Fig. 7

CIP4 promotes distant metastasis in vivo. a Histological image of lung metastasis in nude mice after tail vein injection of 5-8F cells. Scale bar, 500 μm. b The average wet lung weights of the mice were not difference between CIP4 KD and controls. c The numbers of lung metastases (mean ± S.D.) were counted and summarized. ***P < 0.001. d The metastasis rates of CIP4 knockdown 5-8F cells in vivo. The proportion of popliteal lymph node metastases was significantly reduced upon CIP4 silencing in 5-8F cells (n = 30 per group). P values were calculated using a chi-square test