Fig. 5

The recognition and internalization of the DMSNs and RDMSNs in Raji and Jurkat cells, respectively. FCM analysis denotes the mean fluorescence intensity of DOX inside Raji treated with RDMSNs was much higher compared to that of Jurkat cells. Data are presented as mean ± SD from three independent experiments. **, p < 0.01 (a). The Raji cells that were incubated with RDMSNs exhibited strong DOX fluorescence in the cytoplasm. In contrast, the DOX fluorescence that was observed in the cytoplasm of Raji cells incubated with DMSNs was very weak. The cell nucleus were stained with DAPI (blue) (b). TEM images showing the distribution of the RDMSNs within Raji was more compared to that of Jurkat cells. Moreover, more RDMSNs were internalized by Raji cells compared to DMSNs (c)