Fig. 7

Raji cells apoptosis characterizations in vitro. Nuclei morphologic characterizations of Raji cells after different treatment for 24 h at 37 °C under CLSM (1000×, DAPI). The Raji cells that were treated with RDMSNs exhibited the most significantly irregular cell nuclei morphology with shrinkage features compared to those of other groups. Note: Red arrows direct characteristic variations of nucleus (a). Apoptotic rate of Raji cells treated for 24 h at 37 °C by FCM. The apoptosis efficiency of Raji cells that were incubated with RDMSNs was significantly higher than those of other groups (b). Quantitative apoptosis analysis of Raji cells treated with various concentrations of RDMSNs for 24 h at 37 °C. *P < 0.05. The concentration-dependent apoptosis efficiency was detected (c). Data are presented as mean ± SD from three independent experiments.*, P < 0.05; **, p < 0.01