Fig. 8

In vivo biological safety study. H&E staining of major organs obtained from nude mice treated with saline and RMSNs for 3 weeks, respectively. There was no significant pathological lesions or damages in the major organs from nude mice that were treated with RMSNs. Scale bar: 100 μm (a). Body weight of nude mice after treatment with saline and RMSNs showed a gradually increased tendency, implying that RMSNs had a good biocompatibility (n = 3) (b)