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Table 2 Multivariate Cox regression analysis of two gene set signatures for the overall survival of patients with NSCLC

From: Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway

Variable Hazard ratio 95% HR C.I. p-value
11-gene set, overall survival
 Median of risk score 1.425 1.073 1.892 0.0143
 Gender 1.460 0.926 2.300 0.1031
 Age 1.037 1.022 1.052 <0.0001
 Stage (0.1.2 vs. 3.4) 2.990 2.185 4.092 <0.0001
11-gene set, disease-free survival
 Median of risk score 1.341 0.997 1.803 0.0521
 Gender 1.485 0.930 2.371 0.0974
 Age 1.036 1.020 1.051 <0.0001
 Stage (0.1.2 vs. 3.4) 2.941 2.116 4.087 <0.0001
5-gene set, overall survival
 Median of risk score 1.414 1.063 1.882 0.0172
 Gender 1.455 0.923 2.293 0.1060
 Age 1.037 1.022 1.052 <0.0001
 Stage (0.1.2 vs. 3.4) 2.922 2.134 3.999 <0.0001
5-gene set, disease-free survival
 Median of risk score 1.356 1.009 1.823 0.0435
 Gender 1.489 0.933 2.375 0.0950
 Age 1.036 1.021 1.051 <0.0001
 Stage (0.1.2 vs. 3.4) 2.903 2.087 4.037 <0.0001