Fig. 1

E2F8 is widely upregulated in PTC tissues and correlates with more aggressive clinicopathological features. a TCGA dataset showed that E2F8 was significantly upregulated in PTC tissues compared with adjacent normal tissues. b TCGA dataset showed E2F8 was positively correlated with Ki-67(r = 0.7901, p < 0.0001, n = 506) in PTC tissues. c qRT-PCR analysis showed that E2F8 was upregulated in 84.4% of 64 PTC patients (Normalized to adjacent normal tissues). d E2F8 mRNA fold change in different T stages, N stages and TNM stages. e Representative TMA IHC analysis of E2F8 in normal thyroid tissue and PTC tissues in different T stages. f E2F8 staining score was significantly increased in PTC tissues compared with adjacent normal tissues. g E2F8 staining score was significantly increased along with more advanced T stage in PTC tissues. *p < 0.05, **p < 0.01, ***p < 0.001, # No significance