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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Prognostic stratification improvement by integrating ID1/ID3/IGJ gene expression signature and immunophenotypic profile in adult patients with B-ALL

Fig. 2

Determination of groups with differential immunophenotypic markers expression. a Unsupervised hierarchical clustering analysis in diagnosis bone marrow of B-LLA patients according to the expression of the evaluated immunophenotypic markers revealed three main groups of patients. Green bar (group 1) corresponds to the group with high rates of complete remission, low number of patients with positive MRD and absence of patients with t (9; 22). While red bar (group 3) represents the group of patients with the highest percentage of induction failures, positive MRD and all patients with t(9; 22). Blue bar (group 2) represents a small group of patients with intermediate outcome compared with the two groups in the extremes. CR: complete remission. MRD: minimal residual disease. b Expression levels of immunophenotypic markers in the two groups formed at the ends of the heatmap with different clinical features (groups 1 and 3). CD45, CD19, CD38 and FSC have lower expression in group 3 than in group 1. CD10 and Kappa have different high expression in group 3 compared to group 1. The differences are significant (*p = <0.05, ***p = <0.0001). Kaplan Meier curves for event-free survival (c) (p = 0.008) and overall survival (d) (p = 0.559) in the two prognostic groups identified by immunophenotypic profile. Note that EFS curves showed statistically significant differences, whereas the curves for OS did not

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