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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma

Fig. 2

Identification of stem-like features of CD133+/CD24+ cells. The clone formation efficiency of CD133+/CD24+ACHN a and Caki-1 b cells was determined in soft agar. The self-renewal efficiency of CD133+/CD24+ACHN c and Caki-1 d cells was detected by sphere formation assay. The migratory (e and f) and invasive (g and h) capability of CD133+/CD24+ cells were detected by transwell assay. The sensitivity of CD133+/CD24+cells to cisplatin (i and j) and sorafenib (k and l) was determined by MTT. * P < 0.05 VS. control; ** P < 0.01 VS. control;*** P < 0.001 VS. control; Control (Con):parental ACHN or Caki-1 cells)

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