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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma

Fig. 5

The effects of notch signaling on proliferation of RCC CSCs in vivo. a The pharmacological (MRK-003) and endogenous (Numb) notch inhibitor suppressed the growth of RCC CSCs in NOD/SCID mice. (b and d) Immunohistochemistry analysis showed that increased actived-caspase-3 and decreased PCNA were detected in tumor tissue from RCC CSCst reated with RAK-003 or transfected with Numb vector.* P < 0.05 VS. control; ** P < 0.01 VS. control;*** P < 0.001 VS. control; Control (Con): the RCC CSCs treated without inhibitor)

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