|
Variables
| |
Univariate analysis
|
Multivariate analysis
|
|---|
|
Hazard ratio
|
95% CI
|
p-value
|
Hazard ratio
|
95% CI
|
p-value
|
|---|
|
Age
|
≥65
|
2.150
|
1.058 to 4.396
|
0.0345
|
1.691
|
0.798 to 3.588
|
0.1689
|
|
Gender
|
male/female
|
1.193
|
0.581 to 2.436
|
0.6271
| | | |
|
Stage
|
III/IV and Recurrence
|
0.743
|
0.275 to 1704
|
0.5033
| | | |
|
Hb
|
≥13.2
|
0.724
|
0.350 to 1.515
|
0.3859
| | | |
|
NLR
|
≥2.48
|
1.514
|
0.756 to 3.018
|
0.2384
| | | |
|
CEA
|
≥5.3
|
1.791
|
0.879 to 3.813
|
0.1095
| | | |
|
CA19-9
|
≥541
|
1.853
|
0.862 to 3.935
|
0.1120
| | | |
|
IL-6
|
≥0.97
|
0.906
|
0.454 to 1.851
|
0.7816
| | | |
|
PD-1+ CD4+
|
≥1.83
|
2.962
|
1.383 to 6.471
|
0.0054
|
2.546
|
1.138 to 5.765
|
0.0231
|
|
Tim-3+ CD4+
|
≥2.54
|
0.741
|
0.362 to 1.522
|
0.4091
| | | |
|
PD-1+ CD8+
|
≥4.73
|
1.892
|
0.925 to 3.932
|
0.0803
| | | |
|
Tim-3+ CD8+
|
≥4.58
|
0.881
|
0.429 to 1.799
|
0.7269
| | | |
|
Treg
|
≥1.93
|
0.880
|
0.420 to 1.794
|
0.7268
| | | |
|
MDSC
|
≥15.07
|
1.267
|
0.638 to 2.555
|
0.4981
| | | |
- Statistical significant results are highlighted in bold letters
- Abbreviations: HLA human leukocyte antigen, CI confidence interval, Hb hemoglobin, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, NLR neutrophil lymphocyte ration, IL-6 interleukin-6, PD-1 Programmed death-1, Tim-3 T cell immunoglobulin mucin-3, Treg Regulatory T cell, MDSC Myeloid-derived suppressor cell
