Fig. 1

Aberrant expression of HK-2 in hepatocellular carcinoma(HCC). a, HK-2 was highly expressed in HCC cell lines. Western blotting was performed to examine HK-2 expression in several HCC cell lines and normal hepatic cell LO2. b, HK-2 was highly expressed in HCC tissue. Representative figures of immunohistochemical staining for HK-2 in HCC tissues and paired adjacent normal tissue (left panel), statistical results of HK-2 staining in 75 different HCC tissues and matched adjacent normal tissue (right panel). The asterisk (***, p < 0.001) indicated a significant difference of HK-2 expression between tumor and paired adjacent normal tissue