Skip to main content
Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Sex-determining region Y-box protein 3 induces epithelial-mesenchymal transition in osteosarcoma cells via transcriptional activation of Snail1

Fig. 4

SOX3-induced EMT is mediated by Snail1 transcription factor. a siRNA against Snail1 abolished the increased cell ability of migration and invasion produced by SOX3 overexpression. b Snail1 plasmid (Snail1) significantly rescued the decreased cell migration and invasion produced by SOX3 knockdown. c, d the alterations of EMT markers by SOX3 were also reversed by siSnail1 or Snail1 plasmid. The results are expressed as the mean ± SD of triplicate samples; * P < 0.05, **P < 0.01

Back to article page