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Table 2 Univariate and Multivariate Analysis of Factors Associated with Overall Survival

From: The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation

Variable

n

Univariate Analysis

Multivariate Analysis

P

HR (95% CI)

P

HR (95% CI)

Age (year)

 

0.162

 

N.A

 

 <50

45

 

1.011 (1.000–1.034)

  

 ≥50

39

 

1

  

Gender

 

0.856

 

N.A

 

 Female

26

 

1

  

 Male

58

 

1.062 (0.561–2.013)

  

Tumor size (cm)

 

0.39

 

N.A

 

 <5

40

 

0.771 (0.424–1.397)

  

 ≥5

44

 

1

  

Tumor nodule number

 

0.04

 

0.664

 

 Multiple (≥2)

43

 

1.910 (1.033–3.564)

 

1.166 (0.583–2.333)

 Solitary

41

 

1

 

1

Venous invasion

 

0.522

 

N.A

 

 Absence

37

 

1

  

 Presence

47

 

1.217 (0.671–2.224)

  

TNM

 

0.038

 

0.045

 

 I + II

33

 

0.508 (0.217–0.963)

 

0.516 (0.261–0.902)

 III + IV

56

 

1

 

1

BCLC staging

 

0.029

 

0.129

 

 0-A

24

 

0.322 (0.122–0.891)

 

0.442 (0.154–1.267)

 B

23

    

 C

24

    

 D

15

 

1

 

1

Liver function

 

0.696

 

N.A

 

 Child-Pugh A

41

 

1

  

 Child-Pugh B

43

 

1.131 (0.623–2.054)

  

TP73-AS1 expression

 

0.005

 

0.019

 

 Higher

42

 

2.427 (1.311–4.533)

 

2.249 (1.141–4.430)

 Lower

42

 

1

 

1