a. | ||||||||||||
Response to imatinib at 3 months | rs460089 (G/C) | rs2631365 (T/C) | rs13180043 (C/T) | |||||||||
GG | GC | CC | P value Fept | TT | TC | CC | P value Fept | CC | CT | TT | P value Fept | |
EMR (n = 86) | 42 | 33 | 11 | 0.470 | 31 | 45 | 10 | 0.671 | 77 | 9 | 0 | 0.220 |
non-EMR (n = 31) | 19 | 8 | 4 | 12 | 14 | 5 | 25 | 6 | 0 | |||
b. | ||||||||||||
 | rs460089 (G/C)a | rs2631365 (T/C)a | rs13180043 (C/T) a | |||||||||
GG | GC | median/P valueMMT | TT | TC | median/P valueMMT | CC | CT | median/P value MMT | ||||
HT6 median of days (number of cases) | 33.10 (61) | 21.25 (43) | 27.00 p <0.00001 | 32.29 (44) | 25.41 (54) | 27.04 p = 0.223 | 26.46 (100) | 28.34 (17) | 27.00 p = 0.177 | |||
c. | ||||||||||||
 | rs2631365-TC | rs13180043-CC |  |  |  | |||||||
Optimal resp. | Non-optimal resp. | P value Fept | Optimal resp. | Non-optimal resp. | P value Fept | Â | Â | Â | ||||
rs460089-GG | 6 | 15 | 0.00006 | 26 | 33 | 0.0023 | Â | Â | Â | |||
rs460089-GC | 27 | 8 | 30 | 8 | Â | Â | Â | |||||
rs460089-CC | 4 | 0 | 9 | 6 | Â | Â | Â | |||||
d. | ||||||||||||
 | rs460089-GG_ rs2631365-TC (number) | rs460089-GC_ rs2631365_TC (number) | median value/P value MMT | rs460089-GG_ rs13180043-CC (number) | rs460089-GC_ rs13180043-CC (number) | median value/P value MMT |  |  |  | |||
HT6 median of days (number of cases) | 36.34 (18) | 21.48 (34) | 25.41/0.004 | 33.150 (50) | 21.251 (37) | 27.100/0.002 | Â | Â | Â | |||
e. | ||||||||||||
Haplotype rs460089_rs270606_rs156322_rs272872_rs272868_rs2631362_rs274570_rs183898 | European population | Â | Â | Â | Â | Â | Â | Â | Â | |||
G_G_T_G_G_A_C_C | 0.68 | Â | Â | Â | Â | Â | Â | Â | Â | |||
C_A_C_A_C_G_T_G | 0.32 | Â | Â | Â | Â | Â | Â | Â | Â | |||
G_A_C_A_C_G_T_G | 0.003 | Â | Â | Â | Â | Â | Â | Â | Â | |||
C_G_T_G_G_A_C_C | 0.001 | Â | Â | Â | Â | Â | Â | Â | Â | |||
Haplotype rs2631365_rs272842_rs272889_rs2631363_rs274567_rs274559 | Â | Â | Â | Â | Â | Â | Â | Â | Â | |||
T_G_G_A_C_A | 0.58 | Â | Â | Â | Â | Â | Â | Â | Â | |||
C_A_A_G_T_G | 0.42 | Â | Â | Â | Â | Â | Â | Â | Â | |||
C_A_G_A_C_G | 0.004 | Â | Â | Â | Â | Â | Â | Â | Â | |||
C_A_A_A_C_A | 0.001 | Â | Â | Â | Â | Â | Â | Â | Â | |||
C_G_G_A_C_A | 0.001 | Â | Â | Â | Â | Â | Â | Â | Â |