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Table 3 Univariate and multivariate analysis of parameters predictive of outcome

From: Genotypes of SLC22A4 and SLC22A5 regulatory loci are predictive of the response of chronic myeloid leukemia patients to imatinib treatment

 

No MMR

N (%)

MMR

N (%)

OR

95% CI OR

P value

Number

Events

N

HR

CI (95% HR)

P value

Univariate

 Imatinib dose

  Imatinib 400/day

33 (73)

75 (89)

0

0

0

108

37

0

0

0

  Imatinib 200–300 mg/day

12 (27)

9 (11)

2.86

(1.16–7.89)

0.0251

21

11

1.64

(0.84–3.23)

0.1482

 Risk score

  Eutos Low

31 (72)

74 (88)

0

0

0

105

34

0

0

0

  Eutos High

12 (27)

10 (12)

2.86

(1.12–7.32)

0.0452

22

12

1.53

(1.10–2.13)

0.0121

  Sokal Low

13 (31)

42 (50)

0

0

0

55

17

0

0

0

  Sokal Intermediate

11 (26)

30 (36)

1.18

(0.47–3.00)

0.8130

41

9

0.79

(0.46–2.13)

0.5772

  Sokal High

18 (43)

12 (14)

4.85

(1.86–12.65)

0.0019

30

19

1.69

(1.22–2.36)

0.0016

  Hasford Low

11 (26)

30 (36)

0

0

0

41

11

0

0

0

  Hasford Intermediate

18 (43)

47 (56)

1.04

(0.43–2.52)

1.0000

65

21

1.13

(0.55–2.35)

0.7344

  Hasford High

13 (31)

7 (8)

5.06

(1.60–15.99)

0.0058

20

13

1.71

(1.14–2.55)

0.0095

 SNPs

  rs460089

   GG

35 (78)

35 (42)

0

0

0

70

37

0

0

0

   CC

4 (9)

11 (13)

0.36

(0.10–1.25)

0.1530

15

2

0.43

(0.21–0.87)

0.0197

   GC

6 (13)

38 (45)

0.15

(0.06–0.43)

<0.0001

44

9

0.28

(0.13–0.58)

0.0006

  rs13180043

   CC

35 (78)

77 (92)

0

0

0

112

41

0

0

0

   CT

10 (2)

7 (8)

3.14

(1.11–8.94)

0.0321

17

10

1.91

(0.95–3.81)

0.0677

  rs2631365

   TT

19 (42)

31 (37)

0

0

0

50

20

0

0

0

   CC

6 (14)

13 (15)

0.75

0.24–2.32

0.7808

19

4

0.61

(0.35–1.05)

0.0767

   TC

20 (44)

40 (48)

0.82

0.73–1.79

0.6903

60

24

1.00

(0.55–1.82)

0.9900

Multivariate

 Imatinib dose

  Imatinib 400/day

33 (73)

75 (89)

0

0

0

108

37

0

0

0

  Imatinib 200–300 mg/day

12 (27)

9 (11)

4.17

(1.42–12.18)

0.0191

21

11

1.98

(1.01–3.90)

0.0481

 SNP

  rs460089

   GG

35 (78)

35 (42)

0

0

0

70

37

0

0

0

   CC

4 (9)

11 (13)

0.53

(0.27–1.02)

0.0740

15

2

0.40

(0.20–0.83)

0.0141

   GC

6 (13)

38 (45)

0.28

(0.06–0.42)

0.0003

44

9

0.28

(0.14–0.59)

0.0008

  1. Variables with P ≤ 0.05 in the univariate analysis were entered into a multivariate model and odds ratio and hazard ratio was computed for both type of analysis. Multivariate analyzes was performed by logistic regression (MMR) and the Cox proportional hazard regression (EFS). P value <0.05 was considered significant. Eutos score was not available in two patients, Hasford and Sokal scores were not available in three patients