Fig. 3
Gab2 induces tumorigenesis and cell invasion in vivo. a-c 3 × 106 SW480-NC and SW480-Gab2 cells were injected subcutaneously into the right armpit of mice (n = 6 mice per group). Primary tumor growth was examined by measuring tumor volume every week. After 35 days, tumor volume and weight were analyzed. d-f 3 × 106 SW620-si-Ctrl and SW620-Gab2si cells were injected into nude mice subcutaneously (three clones, a-c). g Xenograft tumors were analyzed for Ki67 expression using immunohistochemistry. Lymph nodes in the right armpit of mice were analyzed histologically through hematoxylin and eosin (H&E) staining. *P < 0.05, **P < 0.01 and ***P < 0.001