Fig. 4

Gab2 promotes tumor angiogenesis in a xenograft model. a SW480-NC and SW480-Gab2 tumors were analyzed histologically using H&E staining, as well as for Gab2, CD34 and VEGFR2 using immunohistochemistry. b and c CD34 and VEGFR2-staining vasculature was quantified via measuring the vessel are as (per 200 × field, 5 fields per section) using the Image J software. d The levels of VEGF in SW480-NC and SW480-Gab2 tumors were detected by ELISA assay. The data are representative of at least three different experiments ± SEM. **P < 0.01