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Table 1 Activity of KP46 and obatoclax as compared to standard OS chemotherapeutic agents

From: Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition

Cell Line KP46 (μM) Cisplatin (μM)) Methotrexate (μM) Doxorubicin (nM) Obatoclax (nM)
  IC50 values (mean ± SD)
MG-63 1.204 ± 0.392 7.055 ± 1.6 >50 111.8 ± 87.6 102.9 ± 19.9
HOS 1.210 ± 0.344 6.732 ± 2.5 >50 77.6 ± 16.2 65.1 ± 12.8
U-2 OS 3.830 ± 1.232 8.169 ± 3.2 >50 162.5 ± 123.7 306.7 ± 171.9
SAOS-2 1.641 ± 0.113 5.277 ± 2.1 >50 100.6 ± 4.1 74.0 ± 6.3
HLF 9.01 ± 0.012 3.919 ± 1.2 >50 >250 154.6 ± 15.0