Table 1 Activity of KP46 and obatoclax as compared to standard OS chemotherapeutic agents
Cell Line | KP46 (μM) | Cisplatin (μM)) | Methotrexate (μM) | Doxorubicin (nM) | Obatoclax (nM) |
|---|---|---|---|---|---|
IC50 values (mean ± SD) | |||||
MG-63 | 1.204 ± 0.392 | 7.055 ± 1.6 | >50 | 111.8 ± 87.6 | 102.9 ± 19.9 |
HOS | 1.210 ± 0.344 | 6.732 ± 2.5 | >50 | 77.6 ± 16.2 | 65.1 ± 12.8 |
U-2 OS | 3.830 ± 1.232 | 8.169 ± 3.2 | >50 | 162.5 ± 123.7 | 306.7 ± 171.9 |
SAOS-2 | 1.641 ± 0.113 | 5.277 ± 2.1 | >50 | 100.6 ± 4.1 | 74.0 ± 6.3 |
HLF | 9.01 ± 0.012 | 3.919 ± 1.2 | >50 | >250 | 154.6 ± 15.0 |