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Table 3 IC50 values of Benz and Metformin against various cell linesa

From: Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2

Cell lines

IC50 of Benz (μM)

IC50 of Metformin a (μM)

SW480

143.0 ± 7.0

>1000

Lovo

151.0 ± 4.5

>1000

HCT116

181.4 ± 11.5

>1000

MCF-7

186.0 ± 12.5

>1000

SMMC-7721

210.4 ± 7.9

>1000

LO2

>500

>1000

Vero

>500

>1000

  1. a Metformin was used as positive control. Data were presented as mean ± SEM for three independent experiments