Fig. 8From: FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cellsA schema depicting a mechanism by which FGF2/FGFR1 regulates autophagy. Left panel: FGFR1 activation by FGF2 upregulates ERK1/2 phosphorylation and then downregulates beclin-1, thereby suppresses autophagy. Right panel: FGFR1 inhibition (AZD4547 or FGFR1 knockdown) downregulates phosphorylation of ERK1/2 and subsequently upregulates beclin-1, thereby induces autophagyBack to article page