Fig. 7

FOXM1 mediates resistance to drugs in EOC cells. EOC-CC1 a, c, e, g and OSPC2 b, d, f, h cell lines were transiently transfected with FOXM1-specific siRNA or scramble-siRNA for 24 h. After 48 h, cells were treated with increasing concentrations of the indicated drugs and proliferation rates were estimated by MTS assay. Results shown are representative of three independent experiments. Values were normalized to control cells and represent mean ± SD of quintuplicate determinations. Student’s t test was used for comparisons (*, P ≤ 0.05, **, P ≤ 0.01, ***, P ≤ 0.001, **** P ≤ 0.0001)