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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis

Fig. 6

HSF1 regulates the expression of SMAC and mitochondrial apoptosis pathway-related proteins. a Protein chip cluster analysis of the expression of apoptosis-related proteins in PANC-1 cells after HSF1 silencing. b Protein chip enrichment analysis of the signaling pathway of differentially expressed proteins involved. c and d Western blot analysis of the expression of HSP90, HSP60, HSP27, Bcl-2, BAD, SMAC, cytochrome C. Apaf1, cleaved caspase 3, cleaved caspase 8 and cleaved caspase 9 proteins in PANC-1 cells after HSF1 silencing. The analysis was repeated three times

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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