Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis

Table 2 Multivariate analysis with a Cox proportional hazards regresssion model

Variable	Univariate analysis			Multivariate analysis
Variable	RR	95% CI	P	RR	95% CI	P
Age <45 years	1.023	0.422–2.480	0.960	1.300	0.479–3.523	0.608
(VS. > 45 years)	1.016	0.553–1.867	0.958	0.939	0.410–2.148	0.881
Gender male (VS. female)	0.726	0.384–1.373	0.324	0.886	0.361–2.177	0.792
Drinking history No (VS. Yes)	1.144	0.616–2.124	0.670	2.232	1.007–4.948	0.048
Tumor location Head (VS. Body)	0.699	0.364–1.343	0.283	0.407	0.153–1.082	0.072
Tumor number Solitary (VS. Multipl)	1.378	0.716–2.650	0.337	0.834	0.340–2.051	0.693
Tumor diameter <2 cm (VS. >2 cm)	0.568	0.287–1.124	0.104	0.567	0.229–1.404	0.220
Tumor differentiation I-II (VS. III-IV)	0.379	0.183–0.784	0.009^a	0.379	0.146–0.982	0.048^a

Abbreviation: RR relative risk, CI confidence interval, HSF1 heat shock factor 1
^aSignificant p value

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