Fig. 5

Evaluating the ability of pepstatin A (PepA) to block GAEL-induced cell death. a A2780-cp cells were treated with GLN or MO-101 alone or co-treated with 25 μg/mL PepA for 48 h. While GAEL or GAEL + PepA treatment induced a significant level of cell death, there was no statistical difference in the presence of PepA. b EOC140 cells treated with increasing doses of MO-101 alone or co-treated with 30 μg/mL PepA for 48 h. There is a statistically significant inhibition of cell death in the presence of PepA for two of the conditions, (+), p < 0.05. For both A and B, doses where there is a significant difference in cell viability between cells grown in the presence of drugs compared to vehicle control or PepA alone are indicated by asterisks (***), p < 0.001