Fig. 3

Brivaracetam and lacosamide treatments modulate microRNAs expression in U87MG glioma cells. a Heat map of the identified signature of 37 microRNAs differentially expressed in U87MG cells treated with BRV at IC20 at the indicated time points. b Heat map of the identified signature of 30 microRNAs differentially expressed in U87MG cells treated with LCM at IC20 at the indicated time points. c Supervised statistical test of the significance level of the difference between signal distributions of miR-107 and miR-195-5p in U87MG cells treated with LCM or BRV versus the control (untreated cells). d-e-f qRT-PCR validation of miR-107 and miR-195-5p in U87MG, SW1783 and T98G upon IC20 LCM or BRV treatments at the indicated time points