Fig. 3

ANGPTL1 inhibits liver metastasis in CRC and prolongs OS in vivo. a Histological examination of liver sections from SW620-ANGPTL1 and SW620-Ctrl groups. Liver lesions (black arrow) were confirmed as liver metastasis of CRC. b In the hemi-spleen liver metastasis model, the SW620-ANGPTL1 group had lower incidence of liver metastasis (red circle) and lower radiance intensity of liver lesions than the SW620-Ctrl group, which was illustrated by the in vivo imaging system. In addition, the rate of extrahepatic metastasis (black circle) was also lower in SW620-ANGPTL1 cells. c The mice in the SW620-ANGPTL1 group had longer OS (P = 0.02)