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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells

Fig. 5

ABT-199 targeted Bcl-2 on endothelial cells and inhibited angiogenesis. a HUVEC cells were sorted from the co-culture system for further study, Bcl-2 expression on HUVEC was increased by miR21 overexpression and decreased by ABT-199 treatment in the co-culture system of SU-DHL-4 and SU-DHL-8 cells. b HUVEC were transfected with Bcl-2 siRNA. c-d Molecular silencing of Bcl-2 in HUVEC abrogated ABT-199-mediated reduction of tube formation (c) and induction of cell apoptosis (d). e-g Addition of ICOS antibody in HUVEC counteracted ABT-199-mediated reduction of Bcl-2 expression (e), inhibition of tube formation (f) and induction of cell apoptosis (g)

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