Fig. 6

ABT-199 exhibited in vivo activity on miR21-overexpressing lymphoma. a MiR21-overexpressing pGMLV-miR21 tumors grew more quickly than the control pGMLV-ct tumors and were more sensitive to ABT-199 treatment. b-c p-STAT3-positive Treg cells (b) and ICOS/ICOSL interaction (c) were decreased in untreated pGMLV-miR21 tumors. d-e Bcl-2 expression (d) and cell apoptosis revealed by ultrastructural analysis (e) were increased in microvessels of ABT-199-treated pGMLV-miR21 tumors. Microvessels were indicated by red broken lines and apoptotic bodies by red arrow