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Table 1 Correlation between NLRP3 expression and clinicopathological features in patients with OSCC (n = 103)

From: The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma

Variable

Number

NLRP3 expression

P value*

Ki-67 expression

P value*

Low (32)

High (71)

Low (38)

High (65)

Smoking status**

 Current/former

51

18

33

0.359

20

31

0.629

 Never

52

14

38

 

18

34

 

Alcohol intake***

 Yes

42

12

30

0.650

15

27

0.837

 No

61

20

41

 

23

38

 

Age

  < 60

59

20

39

0.472

22

37

0.923

  ≥ 60

44

12

32

 

16

28

 

Gender

 Male

63

19

44

0.802

26

37

0.298

 Female

30

13

27

 

12

28

 

Location

 Tongue

37

12

25

0.976

10

27

0.228

 Buccal

24

8

16

 

10

14

 

 Gingiva

16

5

11

 

8

8

 

 Mouth floor

13

3

10

 

3

10

 

 Other

13

4

9

 

7

6

 

T stage

 T1 + T2

45

22

23

0.001*

23

22

0.013*

 T3 + T4

58

10

48

 

15

43

 

N stage

 N0

47

16

31

0.550

24

23

0.006*

 N1 + N2

56

16

40

 

14

42

 

M stage

 M0

102

32

70

0.500

39

63

0.433

 M1

1

0

1

 

0

1

 

Differentiation

 Well

39

18

21

0.010*

20

19

0.018*

 Moderate + Poor

64

14

50

 

18

46

 
  1. *P-values are based on chi-squared or Fisher’s exact test. P < 0.05 indicates a significant association among the variables
  2. **Former/current smokers defined as at least a one pack-year history of smoking
  3. ***Alcohol intake was defined as current alcohol intake of more than one drink per day for 1 year. Others were classified as no alcohol intake