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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation

Fig. 4

CTHRC1 facilitates migration and invasion of ESCC cells. Transwell assays were used to investigate migration and invasion of KYSE510 (a), KYSE30 (b) and KYSE450 (c) cells with altered CTHRC1 expression. d, e Representative images of isolated lungs (upper) and H&E-stained lung sections (lower) from each group. The number of mice with micrometastases and the total number of metastatic nodules of each group were also determined. Columns represent the mean number of metastatic nodules of each mouse. The results are shown as the mean ± SD. The P value was generated using two-tailed Student’s t-test. *P < 0.05 and **P < 0.01

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