Fig. 7

mRNA and protein level of CTHRC1, FRA-1, cyclin D1, snail1 and MMP14 in ESCC tissues. a Correlation between CTHRC1 and CCND1 according to transcriptome-wide microarray profiling data (n = 119). Pearson’s correlation coefficient. b Correlation between CTHRC1 and SNAI1 according to transcriptome-wide microarray profiling data (n = 119). Pearson’s correlation coefficient. c Correlation between SNAI1 and MMP14 according to transcriptome-wide microarray profiling data (n = 119). Pearson’s correlation coefficient. d Representative IHC images of FRA-1, snail1, cyclin D1 and MMP14 staining in ESCC tumour tissues. e, f Overall survival analysis based on the level of cyclin D1 and MMP14 expression, as measured by IHC, in ESCC patients. Survival rates were determined using Kaplan-Meier survival analysis