Table 2 Univariate and multivariate analyses of overall survival among patients with ESCC

Age

(≥60 vs <60)

1.958 (1.354–2.832)

1.676 (1.149–2.443)

0.007

Gender

(Male vs Female)

1.178 (0.74–1.876)

Tobacco use

(Yes vs No)

0.869 (0.594–1.271)

Alcohol use

(Yes vs No)

0.890 (0.61–1.297)

Family history

(Yes vs No)

0.646 (0.369–1.130)

Location

(upper/middle vs lower)

0.782 (0.542–1.130)

Histology grade

(3 vs 1/2)

2.056 (1.39–3.041)

1.381 (0.919–2.076)

0.121

T stage

(4 vs 1/2/3)

3.103 (2.085–4.620)

1.335 (0.766–2.326)

0.308

Lymph node metastasis

(Yes vs No)

3.032 (2.055–4.474)

1.637 (1.043–2.570)

0.032

TNM stage

(III vs I/II)

4.209 (2.672–6.632)

2.239 (1.119–4.482)

0.023

CTHRC1

(high vs low)

1.605 (1.074–2.399)

1.157 (0.768–1.743)

0.486