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Fig. 10 | Journal of Experimental & Clinical Cancer Research

Fig. 10

From: Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades

Fig. 10

Schematic showing that ATL effectively inhibits GBM growth. ATL suppressed IKKβ kinase activity and then inhibited the phosphorylation of IKKβ, IκBα and the p65 proteins, promoted the translocation of NF-κB from the cell nuclei to the cytoplasm and attenuated the binding of NF-κB and p300 to the COX-2 promoter, thereby reducing the expression of COX-2. In addition, ATL promoted the release of cyt c from the mitochondria to the cytoplasm and suppressed the expression of cyclin D1, CDK4 and the MMP2/9 proteins

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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