Fig. 8From: Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascadesATL suppresses the growth of tumor xenografts in nude mice. First, we established a subcutaneous transplant tumor model in nude mice by inoculating U87 cells. a: Photographic illustration of tumors from control and ATL-treated nude mice after 15 days of treatment. b-c: Tumor volumes and tumor weights. d: The protein expression of COX-2 and p-p65 in tumor samples by immunohistochemical analysis (original magnification, 400×)Back to article page