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Table 2 Univariate and Multivariate Analysis of Factors Associated with Overall Survival in Breast Cancer Patients

From: Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer

  

Univariate Analysis

Multivariate Analysis

Variable

n

RR(95% CI)

P

RR(95% CI)

P

Age(year)

  ≤ 45

35

1

   

 >45

86

1.416(0.643–3.119)

0.387

n.a.

n.a.

Histological grade

 I

30

1

   

 II- III

91

2.033(0.789–5.241)

0.142

n.a.

n.a.

Positive lymph node

  ≤ 3

83

1

 

1

 

 >3

38

2.159(1.110–4.200)

0.023

1.546(0.194–12.337)

0.681

Lymphovascular invasion

 Absence

73

1

 

1

 

 Presence

48

3.588(1.784–7.216)

<0.001

2.507(1.154–5.447)

0.020

Tumor size(cm)

  ≤ 2

30

1

   

 >2

91

2.338(0.907–6.031)

0.079

n.a.

n.a.

ER

 Positive

83

1

 

1

 

 Negative

38

1.955(1.005–3.804)

0.048

1.432(0.706–2.902)

0.320

PR

 Positive

57

1

   

 Negative

64

1.159(0.593–2.264)

0.666

n.a.

n.a.

Her2

 Negative

67

1

 

1

 

 Positive

54

2.279(1.158–4.485)

0.017

2.254(1.142–4.449)

0.019

TNM stage

 I-II

79

1

 

1

 

 III

42

2.123(1.094–4.122)

0.026

0.440(0.053–3.667)

0.448

CTHRC1 expression

 Low

56

1

 

1

 

 High

65

4.072(1.778–9.329)

0.001

2.559(1.017–6.439)

0.046

  1. Abbreviations: n.a Not application, ER estrogen receptor, PR progesterone receptor, Her2 Human Epidermal Growth Factor Receptor type 2, TNM tumor node metastasis
  2. P < 0.05 was considered statistically significant
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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