Fig. 4

Targets in the curcumin mediated inhibition of breast tumor growth. Curcumin inhibits growth of breast cancer through inhibiting cancer cell proliferation, promoting apoptosis and inducing senescence by means of targeting multiple cell signaling pathways and transcription factors. NFκB: nuclear factor kappa B, MAPK: Mitogen-activated protein kinases, Wnt/β-catenin: Wingless-Int/beta-catenin, IGFR: Insulin like growth factor receptor, IGF1: Insulin like growth factor1, mTOR: mammalian target of rapamycin, ROS: reactive oxygen species, dsDNA: double stranded DNA, STAT3: Signal transducer and activator of transcription3, Nrf2: Nuclear factor (erythroid-derived 2)-like 2, hTERT: human telomerase reverse transcriptase