Fig. 1

The expression of NF2, DNMT1, and miR-152-3p in GBM and malignant glioma cell lines. Normal tissue and GBM were collected to determine mRNA expression of NF2 (a), DNMT1 (b) and miR-152-3p (c), as well as protein expression of NF2 and DNMT1 (d). N, normal brain; G, GBM. Protein expression of NF2 and DNMT1 in HEB, U251, U87, TG-G and A172 cells was evaluated (e). Typical histologic sections of normal tissue and GBM, as well as immunostaining for NF2 and DNMT1 in normal brain and GBM are shown (f). Magnitude 400×. **, P < 0.01 indicated the NF2 expression compared with the expression of control groups. ##, P < 0.01 indicated the DNMT1 expression compared with the expression of control groups