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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma

Fig. 1

miR-500a-3p is upregulated in hepatocellular carcinoma and correlates with poor prognosis. a miR-500a-3p expression level in normal hepatic tissues and hepatocellular carcinoma tissues in the miRNA sequencing dataset of the TCGA hepatocellular carcinoma (Normal, n = 50; Hepatocellular carcinoma, n = 372). P < 0.001. b miR-500a-3p expression level in 49 paired primary hepatocellular carcinoma tissues compared with matched adjacent normal tissues. Transcript levels were normalized to U6 expression. P < 0.001. c Real-time PCR analysis of miR-500a-3p expression in 120 hepatocellular carcinoma tissues compared to the 8 matched adjacent normal hepatic tissues. Transcript levels were normalized to U6 expression. P < 0.05. d miR-500a-3p expression level in 8 paired primary hepatocellular carcinoma tissues compared with matched adjacent normal tissues. Transcript levels were normalized to U6 expression. e miR-500a-3p expression level in one normal hepatic cell and seven hepatocellular carcinoma cells. f Kaplan–Meier analysis of overall and relapse-free survival curves of patients with hepatocellular carcinoma in high miR-500a-3p expression (n = 60) and low miR-500a-3p expression (n = 60). P < 0.001, log-rank test. The data shown in scatter plot and bar graph were determined by the median with interquartile range and median with standard deviation.g Kaplan–Meier analysis of overall survival curves of patients with hepatocellular carcinoma from TCGA in high miR-500a-3p expression (n = 174) and low miR-500a-3p expression (n = 173). P < 0.001

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