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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Akt/FoxM1 signaling pathway-mediated upregulation of MYBL2 promotes progression of human glioma

Fig. 4

FoxM1 and MYBL2 enhance cancer progression in glioma. a Colony formation assays using Hs683 cells, which transfected with GV230-MYBL2 and pcDNA3.1 + HA-FOXM1. b Colony formation assays using U251 cells, which transfected with MYBL2-siRNA and FOXM1-siRNA. c Effects of MYBL2 and FoxM1 silencing on the proliferation of U251 cells. d Cell morphological of U251 cells after silencing MYBL2 and FoxM1. e Representative images from transwell migration assays for U251 cells transfected with MYBL2 and FoxM1 siRNA after 48 h. f The adhesion of siRNA groups and control group to matrix assessed 2 h after plating. g Migration of U251 cells transfected with MYBL2 and FoxM1 siRNAs were identified by wound-healing assays. h The effects of MYBL2 and FoxM1 silencing on the expression of EMT markers and MMPs by Western blotting. *p < 0.05

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