Fig. 4

Tumor growth was suppressed after lentivirus transduction in HN13 cells in nude mice. Lentiviral stable cell lines of stathmin silence was constructed and confirmed in HN4 and HN13 cells. The relative protein expression of stathmin was analyzed using Image J software (a). Using a subcutaneous tumorigenesis model in nude mice, xenograft tumors grew slower in mice injected with HN13 cells transfected with siRNA-stathmin than those transfected with scramble (b). The tumor weight in knockdown group was smaller than scramble control (c). **: P < 0.01, *: P < 0.05